Richard Štefl Research Group 

Structural biology programme harbours research groups that study the intricate and exquisite choreography of life at cellular, molecular and atomic levels. We visualize structural details ranging from cells, their compartments, down to individual proteins, nucleic acids, and their complexes.

The Stefl lab is affiliated with the Central European Institute of Technology Masaryk University (CEITEC) and the National Centre of Biomolecular Research (NCBR) at  We aim to uncover the molecular principles by which biomolecular interactions and conformational dynamics shape biological function and disease. We use cryo-electron microscopy,  nuclear magnetic resonance (NMR) spectroscopy, XL-MS and biochemical and biophysical methods to study how proteins and RNA interact, assemble, and function. Our main focus is on RNA biology, including the structural mechanisms  that drive RNA processing, regulation, and degradation.